Detalhe da pesquisa
1.
ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma.
Nature
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Artigo
em Inglês
| MEDLINE | ID: mdl-33953400
2.
PharmacoDB 2.0: improving scalability and transparency of in vitro pharmacogenomics analysis.
Nucleic Acids Res
; 50(D1): D1348-D1357, 2022 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34850112
3.
Targeting MCL-1 and BCL-2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non-Hodgkin lymphoma: Results from preclinical models and a Phase Ib study.
Am J Hematol
; 98(3): 449-463, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36594167
4.
USP7 small-molecule inhibitors interfere with ubiquitin binding.
Nature
; 550(7677): 534-538, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29045385
5.
Evaluation of statistical approaches for association testing in noisy drug screening data.
BMC Bioinformatics
; 23(1): 188, 2022 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35585485
6.
Reproducible pharmacogenomic profiling of cancer cell line panels.
Nature
; 533(7603): 333-7, 2016 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27193678
7.
Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody-Drug Conjugates.
Mol Pharm
; 15(9): 3979-3996, 2018 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30040421
8.
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Nature
; 487(7408): 505-9, 2012 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22763448
9.
The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity.
Cancer Immunol Res
; 2024 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38489753
10.
Cross-coupling by a noncanonical mechanism involving the addition of aryl halide to Cu(II).
Science
; 381(6662): 1079-1085, 2023 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37676958
11.
An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance.
Nat Cancer
; 4(6): 812-828, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37277530
12.
Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors.
Nat Commun
; 13(1): 2057, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35440108
13.
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers.
Nat Commun
; 13(1): 6814, 2022 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36357397
14.
Orchestrating and sharing large multimodal data for transparent and reproducible research.
Nat Commun
; 12(1): 5797, 2021 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34608132
15.
Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways.
Cancer Discov
; 11(3): 778-793, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33208393
16.
Transcriptional Subtypes Resolve Tumor Heterogeneity and Identify Vulnerabilities to MEK Inhibition in Lung Adenocarcinoma.
Clin Cancer Res
; 27(4): 1162-1173, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33023953
17.
Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines.
iScience
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Artigo
em Inglês
| MEDLINE | ID: mdl-34337362
18.
Towards in vitro in vivo correlation for modified release subcutaneously administered insulins.
Eur J Pharm Sci
; 145: 105239, 2020 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31987985
19.
Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture.
J Cell Biol
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Artigo
em Inglês
| MEDLINE | ID: mdl-15117969
20.
Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation.
Clin Cancer Res
; 25(23): 7202-7217, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31515463